Remove the cards from the layout by clicking on the next card that is one lower or higher than the deck card at the bottom. The Ace is both high and low, either play a 2 or a King on them. If you cannot place any cards from the layout onto the showing card then click the next card button. Wild cards can be placed in any order. The longer your card run, the quicker you will improve your score, so using the wild cards wisely can lead to better scores!
If you can't make a move, click the Next Card to obtain a new one. Try to remove all the cards.